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Int J Biol Macromol. 2018 May;111:493-497. doi: 10.1016/j.ijbiomac.2018.01.043. Epub 2018 Jan 9.

Nasal adhesive patches - Approach for topical application for dry nasal syndrome.

Author information

1
University of Innsbruck, Institute of Pharmacy, Department of Pharmaceutical Technology, Innrain 20-82, 6020 Innsbruck, Austria; Massachusetts Institute of Technology, Koch Institute for Integrative Cancer Research at MIT, Langer Lab, 77 Massachusetts Ave, Cambridge, MA 02139, USA. Electronic address: Flavia.Laffleur@uibk.ac.at.

Abstract

This present study intended to provide nasal adhesive formulations for the topical treatment of dry nasal syndrome. Mucoadhesive films were prepared according to solvent evaporation method consisting of well-known polymers such as gellan and carboxymethyl cellulose. Mucoadhesive films (A-E) were evaluated in respect to their physicochemical properties, stability, disintegration behavior and tensile strength. Moreover, uptake capacity of adhesive films was investigated according to three assays vapor uptake/ permeability and water uptake. Mucoadhesive assessment was carried out on porcine nasal mucosa in terms of adhesion time, wash off resistance and spreadability. Obtained finings indicated 4.2 (B) > 2.55 (A) > 1.8 (D) > 1.3 (C) > 1(E) fold vapor uptake ranking. The bioadhesive results indicated a 60-fold (B) > 8.58-fold (C) > 7.42-fold (E) > 1.3-fold (D) improvement in comparison to formulation A. A variety of humectants such as urea, Aloe vera, allantoin and hyaluronic acid was incorporated in the formulations. Taken together, nasal adhesive films convinced with their proficiency of mucoadhesiveness and stability to be suitable in the management of dry nasal syndrome.

KEYWORDS:

Allantoin; Carboxymethyl cellulose; Film; Gellan; Mucoadhesion; Nasal

PMID:
29329807
DOI:
10.1016/j.ijbiomac.2018.01.043
[Indexed for MEDLINE]

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