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Cell. 2018 Jan 11;172(1-2):318-330.e18. doi: 10.1016/j.cell.2017.12.018.

Color Processing in the Early Visual System of Drosophila.

Author information

1
Department for Animal Physiology and Neurobiology, Institute of Biology I, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany.
2
Tools for Bio-Imaging, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany.
3
Department for Animal Physiology and Neurobiology, Institute of Biology I, Albert-Ludwigs-University Freiburg, 79104 Freiburg, Germany. Electronic address: dierk.reiff@biologie.uni-freiburg.de.

Abstract

Color vision extracts spectral information by comparing signals from photoreceptors with different visual pigments. Such comparisons are encoded by color-opponent neurons that are excited at one wavelength and inhibited at another. Here, we examine the circuit implementation of color-opponent processing in the Drosophila visual system by combining two-photon calcium imaging with genetic dissection of visual circuits. We report that color-opponent processing of UVshort/blue and UVlong/green is already implemented in R7/R8 inner photoreceptor terminals of "pale" and "yellow" ommatidia, respectively. R7 and R8 photoreceptors of the same type of ommatidia mutually inhibit each other directly via HisCl1 histamine receptors and receive additional feedback inhibition that requires the second histamine receptor Ort. Color-opponent processing at the first visual synapse represents an unexpected commonality between Drosophila and vertebrates; however, the differences in the molecular and cellular implementation suggest that the same principles evolved independently.

KEYWORDS:

GECI; color vision; insect; neural circuit; optical imaging; photoreceptor; physiology; presynaptic calcium; retina; sensory processing

PMID:
29328919
DOI:
10.1016/j.cell.2017.12.018
[Indexed for MEDLINE]
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