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J Cell Biochem. 2018 Jul;119(7):5028-5042. doi: 10.1002/jcb.26663. Epub 2018 Mar 12.

Role of immune system in tumor progression and carcinogenesis.

Author information

1
Department of Animal Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India.
2
Department of Biochemistry and Microbial Sciences, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, Punjab, India.

Abstract

Tumor micro-environment has potential to customize the behavior of the immune cell according to their need. In immune-eliminating phase, immune cells eliminate transformed cells but after tumor establishment innate and adaptive immune cells synergistically provide shelter as well as fulfill their requirement that helps in progression. In between eliminating and establishment phase, equilibrium and escaping phase regulate the immune cells response. During immune-escaping, (1) the antigenic response generated is either inadequate, or focused entirely on tolerance, and (2) immune response generated is specific and effective, but the tumor skips immune recognition. In this review, we are discussing the critical role of immune cells and their cytokines before and after the establishment of tumor which might play a critical role during immunotherapy.

KEYWORDS:

adoptive T cell transfer; chemokines; cytokines; immune surveillance; micro-environment

PMID:
29327370
DOI:
10.1002/jcb.26663
[Indexed for MEDLINE]

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