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Drug Discov Today. 2018 Apr;23(4):848-856. doi: 10.1016/j.drudis.2018.01.026. Epub 2018 Jan 8.

Phage-derived lysins as potential agents for eradicating biofilms and persisters.

Author information

1
GangaGen Biotechnologies Pvt. Ltd., No 12, 5th cross, Raghavendra Layout, Tumkur Road, Yeshwantpur, Bangalore, 560022, India. Electronic address: umender@gangagen.com.
2
GangaGen Biotechnologies Pvt. Ltd., No 12, 5th cross, Raghavendra Layout, Tumkur Road, Yeshwantpur, Bangalore, 560022, India.

Abstract

Bacterial biofilms are highly resistant to the action of antibiotics. Presence of persisters, phenotypically resistant populations of bacterial cells, is thought to contribute toward recalcitrance of biofilms. The phage-derived lysins, by virtue of their ability to cleave the peptidoglycan of bacterial cells in an enzymatic manner, have the unique ability to kill dormant cells. Several lysins have shown potent antibiofilm activity in vitro. The fact that lysins have shown better efficacy than conventional drugs in animal models of endocarditis and other infections involving biofilms suggests that the lysins can potentially be developed against difficult-to-treat bacterial infections.

PMID:
29326076
DOI:
10.1016/j.drudis.2018.01.026
[Indexed for MEDLINE]

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