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Fitoterapia. 2018 Mar;125:141-146. doi: 10.1016/j.fitote.2018.01.004. Epub 2018 Jan 8.

Limonoids and triterpenoid from fruit of Swietenia macrophylla.

Author information

1
School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, People's Republic of China.
2
School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, People's Republic of China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, People's Republic of China.
3
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, People's Republic of China.
4
School of Pharmacy, Anhui University of Chinese Medicine, Anhui Key Laboratory of Modern Chinese Materia Medica, Hefei 230012, People's Republic of China; Synergetic Innovation Center of Anhui Authentic Chinese Medicine Quality Improvement, Hefei 230012, People's Republic of China. Electronic address: wanggk@ahtcm.edu.cn.

Abstract

Five new limonoids, swieteliacates A-E (1-5) and a tirucallane-type triterpenoid, swietesenin (6), together with four known compounds (7-10) were isolated from fruit of Swietenia macrophylla. Their structures were determined by spectroscopic analyses. The new compounds were tested in vitro for their cytotoxic effects against five human cancer cell lines. Compound 2 exhibited moderate cytotoxic activities against SW480 and HL-60 cancer cell lines with IC50 values of 30.6 and 32.9μM, respectively.

KEYWORDS:

Cytotoxicity; Limonoids; Swietenia macrophylla; Triterpenoid

PMID:
29325928
DOI:
10.1016/j.fitote.2018.01.004
[Indexed for MEDLINE]

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