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Radiat Oncol J. 2017 Dec;35(4):317-324. doi: 10.3857/roj.2017.00451. Epub 2017 Dec 29.

Treatment results of radiotherapy following CHOP or R-CHOP in limited-stage head-and-neck diffuse large B-cell lymphoma: a single institutional experience.

Author information

1
Department of Radiation Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.
2
Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Hwasun, Korea.

Abstract

PURPOSE:

This study evaluated outcomes of radiotherapy (RT) after chemotherapy in limited-stage head-and-neck diffuse large B-cell lymphoma (DLBCL).

MATERIALS AND METHODS:

Eighty patients who were treated for limited-stage head-and-neck DLBCL with CHOP (n = 43) or R-CHOP (n = 37), were analyzed. After chemotherapy, RT was administered to the extended field (n = 60) or the involved field (n = 16), or the involved site (n = 4). The median dose of RT ranged from 36 Gy in case of those with a complete response, to 45-60 Gy in those with a partial response.

RESULTS:

In all patients, the 5-year overall survival (OS) and disease-free survival (DFS) rates were 83.9% and 80.1%, respectively. In comparison with the CHOP regimen, the R-CHOP regimen showed a better 5-year DFS (86.5% vs. 73.9%, p = 0.027) and a lower rate of treatment failures (25.6% vs. 8.1%, p = 0.040). The volume (p = 0.047) and dose of RT (p < 0.001) were significantly reduced in patients treated with R-CHOP compared to that in those treated with CHOP.

CONCLUSION:

The outcomes of RT after chemotherapy with R-CHOP were better than those of CHOP regimen for limited-stage head-and-neck DLBCL. In patients treated with R-CHOP, a reduced RT dose and volume might be feasible without increasing treatment failures.

KEYWORDS:

Antineoplastic agents; Diffuse large B-cell lymphoma; Head and neck neoplasms; Radiotherapy

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