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J Infect Dis. 2018 Apr 11;217(9):1453-1461. doi: 10.1093/infdis/jiy012.

Adaptation of Staphylococcus aureus to Airway Environments in Patients With Cystic Fibrosis by Upregulation of Superoxide Dismutase M and Iron-Scavenging Proteins.

Author information

1
Institute of Medical Microbiology, Münster.
2
Institute of Microbiology, Ernst-Moritz-Arndt-University, Greifswald.
3
Department of Infectious Diseases, Robert Koch Institute, Wernigerode.
4
Institute of Microbiology, Technical University Braunschweig, Braunschweig, Germany.
5
Microbial Proteomics, Helmholtz Center for Infection Research, Braunschweig, Germany.
6
Institute of Hygiene, University Hospital Münster, Münster.

Abstract

Adaptation of S. aureus to the hostile environment of CF airways resulted in changed abundance of proteins involved in energy metabolism, cellular processes, transport and binding, but most importantly in an iron-scavenging phenotype and increased activity of superoxide dismutase M.

PMID:
29325044
DOI:
10.1093/infdis/jiy012

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