Format

Send to

Choose Destination
Biochemistry. 2018 May 1;57(17):2415-2423. doi: 10.1021/acs.biochem.7b01136. Epub 2018 Jan 24.

Functional Implications of Intracellular Phase Transitions.

Author information

1
Department of Biomedical Engineering and Center for Biological Systems Engineering , Washington University in St. Louis , St. Louis , Missouri 63130 , United States.

Abstract

Intracellular environments are heterogeneous milieus comprised of macromolecules, osmolytes, and a range of assemblies that include membrane-bound organelles and membraneless biomolecular condensates. The latter are nonstoichiometric assemblies of protein and RNA molecules. They represent distinct phases and form via intracellular phase transitions. Here, we present insights from recent studies and provide a perspective on how phase transitions that lead to biomolecular condensates might contribute to cellular functions.

PMID:
29323488
PMCID:
PMC6538385
DOI:
10.1021/acs.biochem.7b01136
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for American Chemical Society Icon for PubMed Central
Loading ...
Support Center