Format

Send to

Choose Destination
Adv Gerontol. 2017;30(5):671-675.

[Functional cumulation of influence of vascular peptide bioregulator on microcirculation in the brain cortex of spontaneously hypertensive rats.]

[Article in Russian; Abstract available in Russian from the publisher]

Author information

1
I. P. Pavlov Institute of Physiology, RAS, 6, Makarova Emb., St. Petersburg, 199034, Russian Federation; sib@kolt.infran.ru.
2
Saint-Petersburg Institute of Bioregulation and Gerontology, 3, Dinamo Av., St. Petersburg, 197110, Russian Federation.

Abstract

in English, Russian

We investigated the influence of vascular peptide bioregulator on microcirculation in the brain cortex of spontaneously hypertensive rats of different ages and figured out whether there is functional cumulation during two-time application of the drug «Slavinorm» by above-mentioned animals. It was shown that a single course treatment with vascular peptide bioregulator had increased the density of microvascular network of the pia mater in young animals ca. 1,2-fold and had not affected the perfusion and oxygen saturation of sensorimotor cortex. The second course treatment with «Slavinorm» was provided in a 6 months. Functional cumulation was revealed in 12 month-aged rats which had 2 course treatments with vascular peptide bioregulation: the density of microvascular network of the pia mater was increased ca. 1,6-fold; level of perfusion was increased ca. 15% in comparison with intact animals of the same age. These animals were more tolerant to cerebral vasospasm (the application of vasoconstrictor on the surface of the brain): the highest level of tissue oxygen saturation was remained at fairly constant perfusion in comparison with other animals.

KEYWORDS:

brain; density of microvascular network; hypertension; oxygen saturation; perfusion; vascular peptide bioregulator; young and old animals

PMID:
29322732

Supplemental Content

Loading ...
Support Center