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Brain Imaging Behav. 2018 Jan 10. doi: 10.1007/s11682-017-9812-x. [Epub ahead of print]

Overlapping and distinct neural metabolic patterns related to impulsivity and hypomania in Parkinson's disease.

Author information

1
Department of Neurology, University Hospital Cologne, Cologne, Germany.
2
Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran. m_tahmasian@sbu.ac.ir.
3
Department of Neurology, University Hospital Marburg, Marburg, Germany.
4
Institute for Cognitive and Brain Sciences, Shahid Beheshti University, Tehran, Iran.
5
Geisinger Commonwealth School of Medicine, Scranton, PA, USA.
6
Institute of Medical Science and Technology, Shahid Beheshti University, Tehran, Iran.
7
Departments of Neuroradiology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
8
TUM-Neuroimaging Center (TUM-NIC), Technische Universität München, Munich, Germany.
9
Department of Psychiatry, Technische Universität München, Munich, Germany.
10
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
11
McGovern Medical School, Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center, Houston, TX, USA.

Abstract

Impulsivity and hypomania are common non-motor features in Parkinson's disease (PD). The aim of this study was to find the overlapping and distinct neural correlates of these symptoms in PD. Symptoms of impulsivity and hypomania were assessed in 24 PD patients using the Barratt Impulsiveness Scale (BIS-11) and Self-Report Manic Inventory (SRMI), respectively. In addition, fluorodeoxyglucose positron emission tomography (FDG-PET) imaging for each individual was performed. We conducted two separate multiple regression analyses for BIS-11 and SRMI scores with FDG-PET data to identify the brain regions that are associated with both impulsivity and hypomania scores, as well as those exclusive to each symptom. Then, seed-based functional connectivity analyses on healthy subjects identified the areas connected to each of the exclusive regions and the overlapping region, used as seeds. We observed a positive association between BIS-11 and SRMI scores and neural metabolism only in the prefrontal areas. Conjunction analysis revealed an overlapping region in the middle frontal gyrus. Regions exclusive to impulsivity were found in the medial part of the right superior frontal gyrus and regions exclusive to hypomania were in the right superior frontal gyrus, right precentral gyrus and right paracentral lobule. Connectivity patterns of seeds exclusively related to impulsivity were different from those for hypomania in healthy brains. These results provide evidence of both overlapping and distinct regions linked with impulsivity and hypomania scores in PD. The exclusive regions for each characteristic are connected to specific intrinsic functional networks.

KEYWORDS:

FDG-PET; Functional connectivity; Hypomania; Impulsivity; Parkinson’s disease

PMID:
29322397
DOI:
10.1007/s11682-017-9812-x

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