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Oncogene. 2018 Mar;37(11):1503-1518. doi: 10.1038/s41388-017-0054-6. Epub 2018 Jan 11.

AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer.

Author information

1
Department II of Internal Medicine, University of Cologne, Cologne, Germany.
2
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
3
Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA.
4
Department I of Internal Medicine, University of Cologne, Cologne, Germany.
5
Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.
6
Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany.
7
Department of Dermatology, University of Cologne, Cologne, Germany.
8
Department of Radiology, University of Cologne, Cologne, Germany.
9
Department of Pathology, University of Cologne, Cologne, Germany.
10
Department of Research, Advanced Diagnostics and Technological Innovation, SAFU Laboratory, Translational Research Area, Regina Elena National Cancer Institute, Rome, Italy.
11
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. christian.reinhardt@uk-koeln.de.
12
Department I of Internal Medicine, University of Cologne, Cologne, Germany. christian.reinhardt@uk-koeln.de.
13
Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. christian.reinhardt@uk-koeln.de.
14
Department II of Internal Medicine, University of Cologne, Cologne, Germany. thomas.benzing@uk-koeln.de.
15
Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. thomas.benzing@uk-koeln.de.
16
Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany. thomas.benzing@uk-koeln.de.
17
Systems Biology of Ageing Cologne (Sybacol), University of Cologne, Cologne, Germany. thomas.benzing@uk-koeln.de.

Abstract

A fundamental principle in malignant tranformation is the ability of cancer cells to escape the naturally occurring cell-intrinsic responses to DNA damage. Tumors progress despite the accumulation of DNA lesions. However, the underlying mechanisms of this tolerance to genotoxic stress are still poorly characterized. Here, we show that replication stress occurs in Kras-driven murine lung adenocarcinomas, as well as in proliferating murine embryonic and adult tissues. We identify the transcriptional regulator AATF/CHE-1 as a key molecule to sustain proliferative tissues and tumor progression in parts by inhibiting p53-driven apoptosis in vivo. In an autochthonous Kras-driven lung adenocarcinoma model, deletion of Aatf delayed lung cancer formation predominantly in a p53-dependent manner. Moreover, targeting Aatf in existing tumors through a dual recombinase strategy caused a halt in tumor progression. Taken together, these data suggest that AATF may serve as a drug target to treat KRAS-driven malignancies.

PMID:
29321668
DOI:
10.1038/s41388-017-0054-6

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