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BMC Infect Dis. 2018 Jan 10;18(1):29. doi: 10.1186/s12879-017-2934-3.

The impact of regular school closure on seasonal influenza epidemics: a data-driven spatial transmission model for Belgium.

Author information

1
Sorbonne Universités, UPMC Univ. Paris 06, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMR-S 1136), Paris, 75012, France.
2
Interuniversity Institute for Biostatistics and Statistical Bioinformatics, Hasselt University, Agoralaan Gebouw D, Diepenbeek, 3590, Belgium.
3
Scientific Institute of Public Health (WIV-ISP), Public Health and Surveillance Directorate, Epidemiology of infectious diseases Service, Rue Juliette/Wytsmanstraat 14, Brussels, 1050, Belgium.
4
Centre for Health Economics Research and Modelling Infectious Diseases, Vaccine and Infectious Disease Institute, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
5
Sorbonne Universités, UPMC Univ. Paris 06, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé Publique (IPLESP UMR-S 1136), Paris, 75012, France. vittoria.colizza@inserm.fr.
6
ISI Foundation, Torino, 10126, Italy. vittoria.colizza@inserm.fr.

Abstract

BACKGROUND:

School closure is often considered as an option to mitigate influenza epidemics because of its potential to reduce transmission in children and then in the community. The policy is still however highly debated because of controversial evidence. Moreover, the specific mechanisms leading to mitigation are not clearly identified.

METHODS:

We introduced a stochastic spatial age-specific metapopulation model to assess the role of holiday-associated behavioral changes and how they affect seasonal influenza dynamics. The model is applied to Belgium, parameterized with country-specific data on social mixing and travel, and calibrated to the 2008/2009 influenza season. It includes behavioral changes occurring during weekend vs. weekday, and holiday vs. school-term. Several experimental scenarios are explored to identify the relevant social and behavioral mechanisms.

RESULTS:

Stochastic numerical simulations show that holidays considerably delay the peak of the season and mitigate its impact. Changes in mixing patterns are responsible for the observed effects, whereas changes in travel behavior do not alter the epidemic. Weekends are important in slowing down the season by periodically dampening transmission. Christmas holidays have the largest impact on the epidemic, however later school breaks may help in reducing the epidemic size, stressing the importance of considering the full calendar. An extension of the Christmas holiday of 1 week may further mitigate the epidemic.

CONCLUSION:

Changes in the way individuals establish contacts during holidays are the key ingredient explaining the mitigating effect of regular school closure. Our findings highlight the need to quantify these changes in different demographic and epidemic contexts in order to provide accurate and reliable evaluations of closure effectiveness. They also suggest strategic policies in the distribution of holiday periods to minimize the epidemic impact.

KEYWORDS:

Epidemic modeling; Influenza; Metapopulation; School closure; Spatial transmission

PMID:
29321005
PMCID:
PMC5764028
DOI:
10.1186/s12879-017-2934-3
[Indexed for MEDLINE]
Free PMC Article

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