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PLoS One. 2018 Jan 10;13(1):e0190505. doi: 10.1371/journal.pone.0190505. eCollection 2018.

Prevalence of hand osteoarthritis and knee osteoarthritis in Kashin-Beck disease endemic areas and non Kashin-Beck disease endemic areas: A status survey.

Lian W1,2, Liu H1,2, Song Q1,2, Liu YQ1,2, Sun LY1,2, Deng Q1,2, Wang SP1,2, Cao YH1,2, Zhang XY3, Jiang YY3, Lv HY3, Duan LB3, Yu J1,2.

Author information

1
Institute for Kashin-Beck Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, China.
2
Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Harbin, China.
3
Jilin Institute of Endemic Disease Prevention second, Jilin, China.

Abstract

Osteoarthritis (OA) is a considerable health problem worldwide, and the prevalence of OA varies in different regions. In this study, the prevalence of OA in Kashin-Beck disease (KBD) and non-KBD endemic areas was examined, respectively. According to monitoring data, 4 types of regions (including none, mild, moderate and high KBD endemic areas) in Heilongjiang and Jilin provinces were selected. All local residents were eligible for inclusion criteria have undergone X-ray images of hands and anteroposterior image of knees. A total of 1673 cases were collected, 1446 cases were analyzed after removing the KBD patients (227). The overall hand OA and knee OA detection rates were 33.3% (481/1446) and 56.6% (818/1446), respectively. After being standardized by age, the detection rate of hand OA in the KBD endemic areas was significantly higher than that in the non-endemic endemic areas. Differently, there was no significant difference in the detection rates of knee OA between the KBD endemic areas and the non-endemic area. The correlation coefficient between the severity of OA and the severity of knee OA was 0.358 and 0.197 in the KBD and non-KBD endemic areas, respectively. Where the KBD historical prevalence level was higher, the severity of the residents' hand OA was more serious. The detection rates of hand OA and knee OA increased with age. The detection rate of knee OA increased with the increase in body mass index. The prevalence of hand OA was closely related to the pathogenic factors of Kashin-Beck disease, and the prevalence of knee OA had no significant correlation with KBD pathogenic factors.

PMID:
29320581
PMCID:
PMC5761882
DOI:
10.1371/journal.pone.0190505
[Indexed for MEDLINE]
Free PMC Article

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