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Eur J Clin Invest. 2018 Mar;48(3). doi: 10.1111/eci.12885. Epub 2018 Feb 2.

Cardiorespiratory fitness and age-related arterial stiffness in women with systemic lupus erythematosus.

Author information

1
Systemic Autoimmune Diseases Unit, Department of Internal Medicine, "Virgen de las Nieves" University Hospital, Granada, Spain.
2
Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain.
3
SPORT Research Group (CTS-1024), CERNEP Research Center, University of Almería, Almería, Spain.
4
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain.

Abstract

BACKGROUND:

The aim of this study was twofold: (i) to examine the association of cardiorespiratory fitness with arterial stiffness in women with systemic lupus erythematosus; (ii) to assess the potential interaction of cardiorespiratory fitness with age on arterial stiffness in this population.

MATERIALS AND METHODS:

A total of 49 women with systemic lupus erythematosus (mean age 41.3 [standard deviation 13.8] years) and clinical stability during the previous 6 months were included in the study. Arterial stiffness was assessed through pulse wave velocity (Mobil-O-Graph® 24 hours pulse wave velocity monitor). Cardiorespiratory fitness was estimated with the Siconolfi step test and the 6-minute walk test.

RESULTS:

Cardiorespiratory fitness was inversely associated with pulse wave velocity in crude analyses (P < .05), although this relationship was attenuated when age and other cardiovascular risk factors were controlled. There was a cardiorespiratory fitness × age interaction effect on pulse wave velocity, regardless of the test used to estimate cardiorespiratory fitness (P < .001 for the Siconolfi step test; P = .005 for the 6-minute walk test), indicating that higher cardiorespiratory fitness was associated with a lower increase in pulse wave velocity per each year increase in age.

CONCLUSIONS:

The results of this study suggest that cardiorespiratory fitness might attenuate the age-related arterial stiffening in women with systemic lupus erythematosus and might thus contribute to the primary prevention of cardiovascular disease in this population. As the cross-sectional design precludes establishing causal relationships, future clinical trials should confirm or contrast these findings.

KEYWORDS:

atherosclerosis; autoimmune diseases; physical fitness; physical function; pulse wave velocity; vascular health

PMID:
29319879
DOI:
10.1111/eci.12885

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