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Angew Chem Int Ed Engl. 2018 Mar 1;57(10):2707-2711. doi: 10.1002/anie.201711845. Epub 2018 Feb 6.

Enantioselective Desymmetrization of Cyclobutanones Enabled by Synergistic Palladium/Enamine Catalysis.

Author information

1
Department of Research Center for Molecular Recognition and Synthesis, Department of Chemistry, Fudan University, 220 Handan Lu, Shanghai, 200433, P.R. China.

Abstract

The enantioselective intramolecular α-arylation of cyclobutanones has been established by combining palladium and enamine catalyst systems. Two different enantioselective control strategies have been developed for cyclobutanone substrates bearing O- or N-tethered aryl bromides. Further synthetic applications are also reported.

KEYWORDS:

arylation; cyclobutanones; desymmetrization; palladium; synergistic catalysis

PMID:
29318758
DOI:
10.1002/anie.201711845

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