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Br J Haematol. 2018 Mar;180(5):727-734. doi: 10.1111/bjh.15082. Epub 2018 Jan 9.

Comparing transfusion reaction risks for various plasma products - an analysis of 7 years of ISTARE haemovigilance data.

Author information

1
Centre for Clinical Transfusion Research, Sanquin Blood Supply, Leiden, the Netherlands.
2
Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.
3
Donor Services Unit, Sanquin Blood Supply, Leiden, the Netherlands.
4
Haemovigilance and Biovigilance Office, TRIP Foundation (Transfusion and transplantation Reactions In Patients), Leiden, the Netherlands.
5
International Haemovigilance Network, ISTARE Steering Committee, Amsterdam, the Netherlands.
6
Panteion University of Social and Political Sciences, Athens, Greece.
7
Coordinating Haemovigilance Centre (SKAE), Hellenic Centre for Disease Control and Prevention, Athens, Greece.
8
Blood Transfusion Centre, Luxembourg Red Cross, Luxembourg City, Luxembourg.
9
Héma-Québec, Montréal, QC, Canada.
10
Department of Haematology, Haga Teaching Hospital, The Hague, the Netherlands.

Abstract

Plasma transfusions may result in transfusion reactions. We used the International Surveillance of Transfusion-Associated Reactions and Events (ISTARE) database, containing yearly reported national annual aggregate data on transfusion reactions from participating countries, to investigate risks of plasma transfusion reactions and compare transfusion reaction risks for different plasma types. We calculated risks for plasma transfusion reactions and compared transfusion reaction risks between plasma types using random effects regression on repeated measures. The ISTARE database contains data from 23 countries, reporting units issued and/or transfused and transfusion reactions observed for some portion of 7 years (2006-2012). Interquartile ranges (IQRs) of plasma transfusion reaction risks were: allergic reactions (5·6-72·2 reactions/105 units transfused); febrile non-haemolytic transfusion reactions (0-9·1); transfusion-associated circulatory overload (0-1·9); transfusion related acute lung injury (TRALI) (0-1·2); and hypotensive reactions (0-0·6). Apheresis plasma was associated with more allergic reactions [odds ratio (OR) = 1·29 (95% confidence interval: 1·19-1·40)] and hypotensive reactions [OR = 2·17 (1·38-3·41)] than whole blood-derived plasma. Pathogen-inactivated plasma was associated with fewer transfusion reactions than untreated plasma.

KEYWORDS:

haemovigilance; plasma transfusion; transfusion reactions

PMID:
29318576
DOI:
10.1111/bjh.15082
[Indexed for MEDLINE]

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