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Gene. 2018 Mar 20;647:235-243. doi: 10.1016/j.gene.2018.01.016. Epub 2018 Jan 6.

The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer.

Author information

1
Biomedical Research Department, Armed Forces College of Medicine (AFCM), Cairo, Egypt.
2
Biochemistry Department, Faculty of Medicine, Minia University, Egypt. Electronic address: magymaher@mu.edu.eg.
3
Armed Forces College of Medicine (AFCM), Cairo, Egypt.

Abstract

The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways. BPA has been associated with serious health effects in humans and wildlife. It elicits several endocrine disorders and plays a role in the pathogenesis of several hormone-dependent tumors such as breast, ovarian, prostate cancer and others. More complicate to this picture, its effects rely on several and diverse molecular and epigenetic mechanisms that converge upon endocrine and reproductive systems. The present review gives an overview of general hazards of BPA, its epigenetic modifications and the molecular mechanisms of BPA action in different types of cancers as the increase in information about responses and action mechanisms of BPA may bring a better understanding of the risks of BPA exposure in humans and provide an important platform on which human health can be improved.

KEYWORDS:

Bisphenol A; Cancer; Endocrine disrupting chemicals; Epigenetics; Molecular signaling

PMID:
29317319
DOI:
10.1016/j.gene.2018.01.016
[Indexed for MEDLINE]

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