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Crit Rev Clin Lab Sci. 2018 Mar;55(2):102-114. doi: 10.1080/10408363.2017.1422692. Epub 2018 Jan 9.

Hodgkin's lymphoma and its association with EBV and HIV infection.

Author information

1
a Department of Pathology, Division of Haematopathology , National Health Laboratory Service, Stellenbosch University , Cape Town , South Africa.
2
b School of Dentistry , Iuliu Hatieganu University of Medicine and Pharmacy , Cluj Napoca , Romania.
3
c Department of Pathology, Division of Anatomical Pathology , National Health Laboratory Service/Stellenbosch University , Cape Town , South Africa.
4
d Department of Pathology , Ion Chiricuta Oncology Institute , Cluj Napoca , Romania.
5
e Department of Oral and Molecular Biology, Faculty of Dentistry , University of the Western Cape , Cape Town , South Africa.
6
f Department of Hematology/Research Center for Functional Genomics and Translational Medicine , Iuliu Hatieganu University of Medicine and Pharmacy - Ion Chiricuta Oncology Institute , Cluj Napoca , Romania.

Abstract

Hodgkin's lymphoma (HL) constitutes a clonal expansion of what appears to be malignant B cells. Viruses are involved in its pathogenesis, such as the Epstein-Barr virus (EBV) and human immunodeficiency virus (HIV). Since these viral infections have been shown to play key roles in the pathogenesis of HL, countries with a prevalence of HIV and EBV represent interesting population targets to study the pathogenesis of HL, linking the evolution of the disease with viral infections. Usually, patients present with late stage disease often involving the bone marrow at the time of diagnosis. The present paper discusses the role of viral infection in African countries, as HL is considered to be a malignant disease characterized by an inflammatory reaction to an aberrant B cell clone that is well known as the Reed-Sternberg cell (HRS).

KEYWORDS:

HIV and EBV infections; Hodgkin’s lymphoma; pathology diagnosis

PMID:
29316828
DOI:
10.1080/10408363.2017.1422692
[Indexed for MEDLINE]

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