Format

Send to

Choose Destination
Int J Mol Sci. 2018 Jan 8;19(1). pii: E184. doi: 10.3390/ijms19010184.

Fungicidal PMMA-Undecylenic Acid Composites.

Author information

1
Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. petrovicmilica21@gmail.com.
2
Faculty of Medicine, University of Nis, 18006 Niš, Serbia. petrovicmilica21@gmail.com.
3
Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. debora.bonvin@gmail.com.
4
Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. heinrich.hofmann@epfl.ch.
5
Powder Technology Laboratory, Institute of Materials, Ecole Polytechnique Fédérale de Lausanne, 1015 Lausanne, Switzerland. marijanamionic@gmail.com.

Abstract

Undecylenic acid (UA), known as antifungal agent, still cannot be used to efficiently modify commercial dental materials in such a way that this affects Candida. Actually, issues with Candida infections and fungal resistance compromise the use of Poly(methyl-methacrylate) (PMMA) as dental material. The challenge remains to turn PMMA into an antifugal material, which can ideally affect both sessile (attached) and planktonic (free-floating) Candida cells. We aimed to tackle this challenge by designing PMMA-UA composites with different UA concentrations (3-12%). We studied their physico-chemical properties, the antifungal effect on Candida and the cytotoxicity toward human cells. We found that UA changes the PMMA surface into a more hydrophilic one. Mainly, as-preparation composites with ≥6% UA reduced sessile Candida for >90%. After six days, the composites were still efficiently reducing the sessile Candida cells (for ~70% for composites with ≥6% UA). Similar results were recorded for planktonic Candida. Moreover, the inhibition zone increased along with the UA concentration. The antifungal effect of UA was also examined at the surface of an UA-loaded agar and the minimal inhibitory concentration (MIC90) was below the lowest-studied 0.0125% UA. Furthermore, the embedded filamentation test after 24 h and 48 h showed complete inhibition of the Candida growth at 0.4% UA.

KEYWORDS:

Candida albicans; PMMA; anti-Candida; antifungal; fungicidal; undecylenic acid

PMID:
29316713
PMCID:
PMC5796133
DOI:
10.3390/ijms19010184
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Multidisciplinary Digital Publishing Institute (MDPI) Icon for PubMed Central
Loading ...
Support Center