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Nutrients. 2018 Jan 6;10(1). pii: E51. doi: 10.3390/nu10010051.

Gelidium elegans Extract Ameliorates Type 2 Diabetes via Regulation of MAPK and PI3K/Akt Signaling.

Author information

1
Department of Food Science and Biotechnology, College of Life Science, CHA University, 463-400 Seongnam, Kyonggi, Korea. wldk3176@gmail.com.
2
Department of Food Science and Biotechnology, College of Life Science, CHA University, 463-400 Seongnam, Kyonggi, Korea. Kuijin.Kim@gmail.com.
3
Department of Food Science and Biotechnology, College of Life Science, CHA University, 463-400 Seongnam, Kyonggi, Korea. kej763@naver.com.
4
Department of Food Science and Biotechnology, College of Life Science, CHA University, 463-400 Seongnam, Kyonggi, Korea. bylee@cha.ac.kr.

Abstract

Gelidium elegans, a red alga native to the Asia Pacific region, contains biologically active polyphenols. We conducted a molecular biological study of the anti-diabetic effect of Gelidium elegans extract (GEE) in C57BL/KsJ-db/db mice. Mice that had been administered GEE had significantly lower body mass, water consumption, and fasting blood glucose than db/db controls. Moreover, hemoglobin A1c (HbA1c), an indicator of the glycemic status of people with diabetes, was significantly lower in mice that had been administered GEE. We also found that 200 mg/kg/day GEE upregulates the insulin signaling pathway by activating insulin receptor substrate-1 (IRS-1) and phosphoinositide 3-kinase (PI3K), and increasing the expression of glucose transporter type 4 (GLUT4). In parallel, mitogen-activated protein kinase (MAPK) activity was lower in GEE-treated groups. In summary, these findings indicate that GEE regulates glucose metabolism by activating the insulin signaling pathway and downregulating the MAPK signaling pathway.

KEYWORDS:

AKT; Gelidium elegans extract; MAPK pathways; diabetic symptoms; glucose uptake; type 2 diabetes

PMID:
29316644
PMCID:
PMC5793279
DOI:
10.3390/nu10010051
[Indexed for MEDLINE]
Free PMC Article

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