Format

Send to

Choose Destination
Dev Cell. 2018 Jan 8;44(1):3-4. doi: 10.1016/j.devcel.2017.12.015. Epub 2018 Jan 8.

Smoothened Sensor Places Sodium and Sterols Center Stage.

Author information

1
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
2
The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. Electronic address: james.briscoe@crick.ac.uk.

Abstract

Regulation of Smoothened by PTCH1 is central to Hedgehog signal transduction. Reporting recently in PNAS, Myers et al. (2017) provide evidence that a transmembrane flux of sodium ions drives PTCH1 activity and that cholesterol regulates Smoothened via its transmembrane domain.

PMID:
29316438
DOI:
10.1016/j.devcel.2017.12.015
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center