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J Altern Complement Med. 2018 Jan;24(1):37-47. doi: 10.1089/acm.2016.0379. Epub 2018 Jan 9.

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment.

Author information

1
1 Kemin Foods, LC , Des Moines, IA.
2
2 Biofortis Research Services/Mérieux NutriSciences , Addison, IL.
3
3 Bracket, LLC , Wayne, PA.
4
4 Department of Psychology, Northumbria University , Newcastle, United Kingdom .
5
5 Centre for Human Psychopharmacology, Swinburne University , Melbourne, Australia .

Abstract

OBJECTIVE:

The purpose of this study was to investigate the effects of supplementation with a spearmint (Mentha spicata L.) extract, high in polyphenols including rosmarinic acid, on cognitive performance, sleep, and mood in individuals with age-associated memory impairment (AAMI).

DESIGN:

Subjects with AAMI (N = 90; 67% female; age = 59.4 ± 0.6 years) were randomly assigned (n = 30/group) to consume 900, 600, or 0 mg/day (two capsules, once daily) spearmint extract for 90 days, in this double-blind, placebo-controlled trial. Assessments were completed for cognition (days 0, 45, and 90), sleep (days 0 and 90), and mood (days 0 and 90) by using the Cognitive Drug Research (CDR) System, Leeds Sleep Evaluation Questionnaire (LSEQ), and Profile of Mood States (POMS), respectively.

RESULTS:

Quality of working memory and spatial working memory accuracy improved after supplementation with 900 mg/day spearmint extract by 15% (p = 0.0469) and 9% (p = 0.0456), respectively, versus placebo. Subjects consuming 900 mg/day spearmint extract reported improvement in their ability to fall asleep, relative to subjects consuming placebo (p = 0.0046). Overall treatment effects were evident for vigor-activity (p = 0.0399), total mood disturbance (p = 0.0374), and alertness and behavior following wakefulness (p = 0.0415), with trends observed for improvements after spearmint supplementation relative to placebo.

CONCLUSIONS:

These results suggest that the distinct spearmint extract may be a beneficial nutritional intervention for cognitive health in older subjects with AAMI.

KEYWORDS:

polyphenols; rosmarinic acid; sleep; spearmint; working memory

PMID:
29314866
PMCID:
PMC5779242
DOI:
10.1089/acm.2016.0379
[Indexed for MEDLINE]
Free PMC Article

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