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Pediatr Blood Cancer. 2018 May;65(5):e26924. doi: 10.1002/pbc.26924. Epub 2018 Jan 4.

Exercise program for children and adolescents with leukemia and lymphoma during treatment: A comprehensive review.

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Pediatric Oncohematology, Stem Cell Transplantation and Cell Therapy Division, A.O.U. Città della Salute e della Scienza-Regina Margherita Children's Hospital, Turin, Italy.
Rehabilitation Service, Public Health and Pediatric Sciences Department, A.O.U. Città della Salute e della Scienza-Regina Margherita Children Hospital, Turin, Italy.
PEER Program Coordinator at the Kids Cancer Care of Alberta, Calgary, Alberta, Canada.


An exercise program (EP) during cancer treatment seems to be a valid strategy against physiological and quality-of-life impairments, but scientific evidence of benefits among pediatric patients is still limited. This review summarizes the literature focused on randomized controlled trials of EP offered to patients during leukemia and lymphoma treatment. Studies published up to June 2017 were selected from multiple databases and assessed by three independent reviewers for methodological validity. The review identified eight studies, but several types of bias have to be avoided to provide evidence-based recommendations accessible to patients, families, and professionals.


exercise program; neurotoxicity of therapies; pediatric oncology; supportive care

[Indexed for MEDLINE]

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