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Pediatr Allergy Immunol. 2018 May;29(3):311-317. doi: 10.1111/pai.12859. Epub 2018 Feb 6.

Association between pro-inflammatory alleles and allergic phenotypes in Xhosa adolescents.

Author information

1
Department of Paediatrics and Child Health, Red CrossWar Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
2
Statistics Department, University of Western Cape, Cape Town, South Africa.
3
School of Public Health, Curtin University, Perth, WA, Australia.
4
School of Paediatrics and Child Health, Faculty of Medicine, Dentistry and Health Sciences, University of Western Australia, Perth, WA, Australia.
5
Department of Respiratory Medicine, Princess Margaret Hospital for Children, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
6
Division of Allergology, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.

Abstract

BACKGROUND:

Significant differences exist in the prevalence, spectrum, and severity of allergic diseases between developing and developed countries and between subpopulations within single countries. These discrepancies likely result from a complex interaction between genetic and environmental factors. However, the precise nature of the contribution of ethnicity to genetic differences in the predisposition to allergic disease is not yet fully understood. In particular, there is a paucity of literature regarding the genetic determinants of allergic disease in people of black African origin with little or no genetic admixture.

OBJECTIVE:

We aimed to analyze associations between 27 single nucleotide polymorphisms (SNPs) and allergy phenotypes in the local Xhosa population.

METHODS:

A convenience sample of 213 Xhosa teenagers was enrolled at a local high school. Phenotypic data were collected in the form of a symptom questionnaire, skin prick tests for common food and aeroallergens, total serum IgE, and IgE to Ascaris lumbricoides. In addition, genotyping was performed to establish the prevalence of putative pro-inflammatory alleles.

RESULTS:

We demonstrated several significant associations between polymorphisms and allergy phenotypes. In particular, 2 polymorphisms in the IL-10 gene (IL10 -592A>C and IL10 -1082A>G) and 1 in the IL-4 gene (IL4 -589C>T) showed multiple associations with allergic sensitization and asthma phenotypes. Other polymorphisms, across a multitude of genes with discrepant functions, showed less consistent associations.

CONCLUSION:

This study represents an important first step in genotype/phenotype association in this population. Further research is required to confirm or refute our findings.

KEYWORDS:

African; IL-10; IL-4; Xhosa; allergy; association; asthma; polymorphism

PMID:
29314322
DOI:
10.1111/pai.12859
[Indexed for MEDLINE]

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