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Autophagy. 2018;14(3):558-559. doi: 10.1080/15548627.2018.1425060. Epub 2018 Feb 21.

Transcriptomic insights into temporal expression pattern of autophagy genes during monocytic and granulocytic differentiation.

Author information

1
a College of Bioinformatics Science and Technology, Harbin Medical University , Harbin , China.
2
b State Key Laboratory of Medical Molecular Biology, Department of Biochemistry & Molecular Biology , Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and Peking Union Medical College (PUMC) , Beijing , China.
3
c Center for Informational Biology , University of Electronic Science and Technology of China , Chengdu , China.

Abstract

Macroautophagy/autophagy plays an essential role in hematopoietic stem cell (HSC) differentiation. However, the role of autophagy during monocytic and granulocytic differentiation remains poorly understood. Hence, we first represented global transcriptomic analysis for temporal expression of autophagy genes during monocytic and granulocytic differentiation by combining RNA-Seq data with monocytic and granulocytic induction in CD34+ hematopoietic stem and progenitor cells. According to a self-organizing map (SOM) algorithm, our results show temporal expression patterns of autophagy genes during monocytic and granulocytic differentiation. More importantly, 22 autophagy genes present significantly divergent roles during monocytic and granulocytic differentiation, indicating these autophagy genes could be important factors involved in the differentiation of myeloid progenitors into monocytes and granulocytes.

KEYWORDS:

autophagy; hematopoietic stem cell; monocytic and granulocytic differentiation; temporal expression pattern; transcriptomic analysis

PMID:
29313406
PMCID:
PMC5915022
[Available on 2019-02-21]
DOI:
10.1080/15548627.2018.1425060

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