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Sci Rep. 2018 Jan 8;8(1):99. doi: 10.1038/s41598-017-18320-y.

Home Exercise Training Improves Exercise Capacity in Cirrhosis Patients: Role of Exercise Adherence.

Author information

1
Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
2
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada.
3
Liver Health Clinic, Royal Alexandra Hospital, Edmonton, AB, Canada.
4
Department of Biomedical Engineering, University of Alberta, Edmonton, AB, Canada.
5
Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
6
College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, Texas, USA.
7
Cirrhosis Care Clinic, Department of Medicine, University of Alberta, Edmonton, AB, Canada. ptandon@ualberta.ca.
8
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB, Canada. ptandon@ualberta.ca.

Abstract

Cirrhosis patients have reduced peak aerobic power (peak VO2) that is associated with reduced survival. Supervised exercise training increases exercise tolerance. The effect of home-based exercise training (HET) in cirrhosis is unknown. The objective was to evaluate the safety and efficacy of 8 weeks of HET on peak VO2, 6-minute walk distance (6MWD), muscle mass, and quality of life in cirrhosis. Random assignment to 8 weeks of HET (moderate to high intensity cycling exercise, 3 days/week) or usual care. Exercise adherence defined as completing ≥80% training sessions. Paired t-tests and analysis of covariance used for comparisons. Forty patients enrolled: 58% male, mean age 57 y, 70% Child Pugh-A. Between group increases in peak VO2 (1.7, 95% CI: -0.33 to 3.7 ml/kg/min, p = 0.09) and 6MWD (33.7, 95% CI: 5.1 to 62.4 m, p = 0.02) were greater after HET versus usual care. Improvements even more marked in adherent subjects for peak VO2 (2.8, 95% CI: 0.5-5.2 mL/kg/min, p = 0.02) and 6MWD (46.4, 95% CI: 12.4-80.5 m, p = 0.009). No adverse events occurred during testing or HET. Eight weeks of HET is a safe and effective intervention to improve exercise capacity in cirrhosis, with maximal benefits occurring in those who complete ≥80% of the program.

PMID:
29311671
PMCID:
PMC5758716
DOI:
10.1038/s41598-017-18320-y
[Indexed for MEDLINE]
Free PMC Article

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