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Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02069-17. doi: 10.1128/AAC.02069-17. Print 2018 Mar.

Neisseria cinerea with High Ceftriaxone MIC Is a Source of Ceftriaxone and Cefixime Resistance-Mediating penA Sequences in Neisseria gonorrhoeae.

Author information

1
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
2
Department of Clinical Infectious Diseases, Aichi Medical University, Aichi, Japan.
3
WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden.
4
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan ohnishi7@nih.go.jp.
5
Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan.

Abstract

Mosaic penA alleles have caused most of the cephalosporin resistance in Neisseria gonorrhoeae, but their evolution is mostly unknown. The penA gene from Neisseria cinerea strain AM1601 (ceftriaxone MIC, 1.0 μg/ml) caused ceftriaxone resistance (MIC, 1 μg/ml) in a ceftriaxone-susceptible gonococcal strain. The 3'-terminal half of AM1601 penA was almost identical to that of the ceftriaxone-resistant gonococcal GU140106 and FC428 strains. N. cinerea can serve as a reservoir of ceftriaxone resistance-mediating penA sequences that can be transferred to gonococci.

KEYWORDS:

Neisseria cinerea; Neisseria gonorrhoeae; antimicrobial resistance; cefixime; ceftriaxone; penA; penicillin-binding protein 2

PMID:
29311079
PMCID:
PMC5826163
DOI:
10.1128/AAC.02069-17
[Indexed for MEDLINE]
Free PMC Article

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