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Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02227-17. doi: 10.1128/AAC.02227-17. Print 2018 Mar.

Enhanced Efflux Pump Activity in Old Candida glabrata Cells.

Author information

1
Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, New York, USA.
2
Division of Infectious Diseases, Department of Medicine, Stony Brook University, Stony Brook, New York, USA bettina.fries@stonybrookmedicine.edu.
3
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, New York, USA.

Abstract

We investigated the effect of replicative aging on antifungal resistance in Candida glabrata Our studies demonstrate significantly increased transcription of ABC transporters and efflux pump activity in old versus young C. glabrata cells of a fluconazole-sensitive and -resistant strain. In addition, higher tolerance to killing by micafungin and amphotericin B was noted and is associated with higher transcription of glucan synthase gene FKS1 and lower ergosterol content in older cells.

KEYWORDS:

Candida glabrata; aging; antifungal resistance; drug resistance mechanisms; efflux pumps

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