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Int J Biol Macromol. 2018 May;111:311-318. doi: 10.1016/j.ijbiomac.2018.01.005. Epub 2018 Jan 5.

The characterization, selenylation and anti-inflammatory activity of pectic polysaccharides extracted from Ulmus pumila L.

Author information

1
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea.
2
Department of Biotechnology, Korea University, Seoul 02481, Republic of Korea; Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do 13539, Republic of Korea.
3
Division of Functional Food Research, Korea Food Research Institute, Gyeonggi-do 13539, Republic of Korea.
4
Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Republic of Korea. Electronic address: yhchang@khu.ac.kr.

Abstract

The specific objective of this study was to investigate characterization, selenylation, and anti-inflammatory activities of pectic polysaccharides extracted from Ulmus pumila L. (PPU). Four different monosaccharides were found in PPU, including galacturonic acid, galactose, rhamnose, and glucose. FT-IR spectra indicated that pectic polysaccharides were successfully extracted from Ulmus pumila L., and were probably low methoxyl pectin. GC-MS and NMR analysis of PPU suggested the major monosaccharide of PPU was α-1,4-linked galacturonic acid with α-1,2-linked rhamnose as the backbone and glucose or galactose residues as branches at C-3 and C-4 positions of rhamnose. Selenylation of PPU was synthesized by 0.2 and 0.4% of sodium selenites. Selenized-PPU (Se-PPU) inhibited LPS-induced nitric oxide production in RAW 264.7 cells, and increasing selenium content enhanced anti-inflammatory properties of PPU. Therefore, Se-PPU can be used as a potential source of bioactive compounds for nutraceuticals and pharmaceutical applications.

KEYWORDS:

Anti-inflammatory properties; Pectic polysaccharide; Selenylation; Structural analysis; Ulmus pumila L.

PMID:
29309871
DOI:
10.1016/j.ijbiomac.2018.01.005
[Indexed for MEDLINE]

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