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J Microencapsul. 2018 Jan;35(1):90-101. doi: 10.1080/02652048.2018.1425752. Epub 2018 Jan 21.

Self-double-emulsifying drug delivery system incorporated in natural hydrogels: a new way for topical application of vitamin C.

Wang Q1,2,3, Zhang H1,3, Huang J1,3, Xia N1,3, Li T1,3, Xia Q1,2,3.

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a State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering , Southeast University , Nanjing , China.
b National Demonstration Center for Experimental Biomedical Engineering Education , Southeast University , Nanjing , China.
c Collaborative Innovation Center of Suzhou Nano Science and Technology , Suzhou , Jiangsu , China.


This study aimed at the in vitro evaluation of topical hydrogels containing vitamin C-loaded self-double-emulsifying drug delivery system (SDEDDS). The liquid SDEDDS was converted into suitable unmodified xanthan gum hydrogels formulation and the prepared semi-solid hydrogels provided appropriate gel characteristics like pH, viscosity, spreadability, etc. The 5-week storage test displayed that the prepared hydrogels possessed good physicochemical stability. In addition, no significant cytotoxicity to L929 cells was observed for the vitamin C-loaded SDEDDS-based hydrogels, and the prepared hydrogels depicted a sustained drug release over an 8-h period. In vitro permeation study showed that the vitamin C-loaded SDEDDS-based hydrogels could significantly enhance vitamin C retention in the skin and permeation through the skin. The overall results demonstrated that the hydrogels containing vitamin C-loaded SDEDDS could be considered as a promising formulation for topical application.


Vitamin C; hydrogels; self-double-emulsifying drug delivery system; topical application; xanthan gum

[Indexed for MEDLINE]

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