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Bull Exp Biol Med. 2018 Jan;164(3):324-329. doi: 10.1007/s10517-018-3982-4. Epub 2018 Jan 8.

Algorithm of Molecular and Biological Assessment of the Mechanisms of Sensitivity to Drug Toxicity by the Example of Cyclophosphamide.

Author information

1
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, Moscow, Russia. tell2003@post.ru.
2
Institute for Advanced Studies, Federal Medical-Biological Agency, Moscow, Russia.
3
Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia.

Abstract

Comparative study of the liver, blood, and spleen of DBA/2JSto and BALB/cJLacSto mice sensitive and resistant to acute toxicity of the cyclophosphamide allowed us to reveal basic toxicity biomarkers of this antitumor and immunosuppressive agent. Obtained results can be used for the development of an algorithm for evaluation of toxic effects of drugs and food components.

KEYWORDS:

BALB/cJLacSto and DBA/2JSto mice; acute toxicity; biomarkers; cyclophosphamide

PMID:
29308567
DOI:
10.1007/s10517-018-3982-4
[Indexed for MEDLINE]

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