Format

Send to

Choose Destination
Int J Hyperthermia. 2018 Dec;34(8):1367-1371. doi: 10.1080/02656736.2018.1424946. Epub 2018 Jan 17.

Randomized trial of preoperative administration of oral pregabalin for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in the liver.

Author information

1
a Department of Anesthesia , Tanta University , Tanta , Egypt.
2
b Department of Physiology , Tanta University Faculty of Medicine , Tanta , Egypt.
3
c Department of Tropical Medicine , Tanta University , Tanta , Egypt.
4
d Department of Internal Medicine , Zagazig University Faculty of Human Medicine , Zagazig , Egypt.
5
e Department of Tropical Medicine , Tanta University Faculty of Medicine , Tanta , Egypt.

Abstract

PURPOSE:

The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs).

METHODS:

This randomised controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomised into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour before the procedure. The primary outcome was the analgesic effect in the form of postoperative pain severity and the need for opioid analgesics.

RESULTS:

In the immediate postoperative period there was no significant difference between the two groups on pain assessment by the visual analogue pain scale (VAS Pain; p = 0.84). However, the medians of Group II VAS Pain were significantly (p < 0.001) less than Group I 3,2,1,1,1,0 vs. 4,3,3,2,2,2, respectively when measured every four hours until 24 hours. The number of required doses of rescue analgesia and total required dose of morphine in the first 48 hours postoperatively of Group II were significantly (p < 0.001) less than Group I. Side effects such as nausea and vomiting and delayed discharge were significantly less frequent in Group II when compared with Group I:20vs. 45.7%, 17.1 vs. 45.7% and 11.4 vs. 37.1%, respectively (p = 0.02, 0.01 and 0.01, respectively).

CONCLUSION:

Pre-emptive oral pregabalin is safe and effective for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in liver.

KEYWORDS:

HCC; Pregabalin; analgesia; liver cancer; radiofrequency ablation

PMID:
29308685
DOI:
10.1080/02656736.2018.1424946
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center