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Br J Nutr. 2018 Jan;119(2):176-189. doi: 10.1017/S0007114517003440. Epub 2018 Jan 8.

Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study.

Author information

1
1School of Food and Nutrition,Massey Institute of Food Science and Technology,Massey University,Palmerston North 4442,New Zealand.
2
3Faculty of Medical and Health Sciences,The University of Auckland,Auckland 1142,New Zealand.
3
2Food, Nutrition and Health,The New Zealand Institute for Plant & Food Research Limited,Palmerston North 4474,New Zealand.
4
4Faculty of Life Sciences and Medicine,Diabetes and Nutritional Sciences Division,King's College London,London SE1 9NH,UK.

Abstract

Dysbiotic gut microbiota have been implicated in human disease. Diet-based therapeutic strategies have been used to manipulate the gut microbiota towards a more favourable profile. However, it has been demonstrated that large inter-individual variability exists in gut microbiota response to a dietary intervention. The primary objective of this study was to investigate whether habitually low dietary fibre (LDF) v. high dietary fibre (HDF) intakes influence gut microbiota response to an inulin-type fructan prebiotic. In this randomised, double-blind, placebo-controlled, cross-over study, thirty-four healthy participants were classified as LDF or HDF consumers. Gut microbiota composition (16S rRNA bacterial gene sequencing) and SCFA concentrations were assessed following 3 weeks of daily prebiotic supplementation (Orafti® Synergy 1; 16 g/d) or placebo (Glucidex® 29 Premium; 16 g/d), as well as after 3 weeks of the alternative intervention, following a 3-week washout period. In the LDF group, the prebiotic intervention led to an increase in Bifidobacterium (P=0·001). In the HDF group, the prebiotic intervention led to an increase in Bifidobacterium (P<0·001) and Faecalibacterium (P=0·010) and decreases in Coprococcus (P=0·010), Dorea (P=0·043) and Ruminococcus (Lachnospiraceae family) (P=0·032). This study demonstrates that those with HDF intakes have a greater gut microbiota response and are therefore more likely to benefit from an inulin-type fructan prebiotic than those with LDF intakes. Future studies aiming to modulate the gut microbiota and improve host health, using an inulin-type fructan prebiotic, should take habitual dietary fibre intake into account.

KEYWORDS:

HDF high dietary fibre; LDF low dietary fibre; 16S rRNA gene sequencing; Gut microbiota; Habitual dietary fibres; Inulin-type fructan prebiotics; Responsiveness

PMID:
29307330
DOI:
10.1017/S0007114517003440
[Indexed for MEDLINE]

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