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J Pediatr. 2018 Apr;195:292-296.e3. doi: 10.1016/j.jpeds.2017.11.029. Epub 2018 Jan 3.

Outcomes of Surgical Ligation after Unsuccessful Pharmacotherapy for Patent Ductus Arteriosus in Neonates Born Extremely Preterm.

Author information

1
Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, Toronto, Canada; Department of Pediatrics, University of Toronto, Toronto, Canada. Electronic address: dany.weisz@sunnybrook.ca.
2
Phoenix Children's Hospital, Phoenix, AZ.
3
Department of Pediatrics, Mt. Sinai Hospital, Toronto, Canada.
4
Department of Pediatrics, University of Toronto, Toronto, Canada; Department of Pediatrics, Hospital for Sick Children, Toronto, Canada.
5
Department of Newborn and Developmental Pediatrics, Sunnybrook Health Sciences Centre, Toronto, Canada; Department of Pediatrics, University of Toronto, Toronto, Canada.
6
Department of Medicine, University of Toronto, Toronto, Canada.
7
Department of Pediatrics, University of Toronto, Toronto, Canada; Department of Pediatrics, Mt. Sinai Hospital, Toronto, Canada; Department of Physiology, University of Toronto, Toronto, Canada; Physiology and Experimental Medicine, SickKids Research Institute, Toronto, Canada.
8
Department of Pediatrics, University of Toronto, Toronto, Canada; Department of Pediatrics, Hospital for Sick Children, Toronto, Canada; Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada.

Abstract

A retrospective cohort study of neonates born extremely preterm with persistent patent ductus arteriosus after unsuccessful pharmacologic closure compared outcomes between 166 surgically ligated and 142 nonligated neonates. After adjustment for confounders, ligation was not associated with the composite outcome of death or neurodevelopmental impairment, neurodevelopmental impairment alone, chronic lung disease, or retinopathy of prematurity among survivors.

KEYWORDS:

PDA; cerebral palsy; chronic lung disease; confounding by indication; mortality; neurosensory impairment; nonsteroidal anti-inflammatory drug; retinopathy of prematurity; selection bias; survival bias

PMID:
29306492
DOI:
10.1016/j.jpeds.2017.11.029
[Indexed for MEDLINE]

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