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J Neuroimmunol. 2018 Feb 15;315:24-27. doi: 10.1016/j.jneuroim.2017.12.009. Epub 2017 Dec 19.

Effects of lipoic acid on migration of human B cells and monocyte-enriched peripheral blood mononuclear cells in relapsing remitting multiple sclerosis.

Author information

1
VA Portland Health Care System, Research and Development Service, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA.
2
VA Portland Health Care System, Research and Development Service, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
3
VA Portland Health Care System, Research and Development Service, 3710 SW US Veterans Hospital Rd., Portland, OR 97239, USA; Department of Neurology, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA. Electronic address: Salintho@ohsu.edu.

Abstract

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation and demyelination resulting in clinical disability. The rodent MS model suggests that infiltration of monocytes and B cells contributes to disease pathogenesis. Here, we compared the migratory capacity of human monocytes and B cells from healthy control (HC) and relapsing-remitting MS (RRMS) subjects, with or without lipoic acid (LA) treatment. Basal migration of monocyte-enriched PBMCs from RRMS subjects is significantly higher than HC PBMCs. LA treatment significantly inhibits monocyte and B cell migration in both cohorts, and may thus be therapeutically effective for treatment of MS.

KEYWORDS:

B cell; Lipoic acid; Migration; Monocyte; RRMS

PMID:
29306401
DOI:
10.1016/j.jneuroim.2017.12.009
[Indexed for MEDLINE]

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