Format

Send to

Choose Destination
J Neuroimmunol. 2018 Feb 15;315:15-23. doi: 10.1016/j.jneuroim.2017.12.016. Epub 2017 Dec 19.

Crosstalk between cancer and the neuro-immune system.

Author information

1
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia.
2
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia. Electronic address: Vasso.Apostolopoulos@vu.edu.au.
3
Centre for Chronic Disease, College of Health and Biomedicine, Victoria University, Melbourne, Australia. Electronic address: Kulmira.Nurgali@vu.edu.au.

Abstract

In the last decade, understanding of cancer initiation and progression has been given much attention with studies mainly focusing on genetic abnormalities. Importantly, cancer cells can influence their microenvironment and bi-directionally communicate with other systems such as the immune system. The nervous system plays a fundamental role in regulating immune responses to a range of disease states including cancer. Its dysfunction influences the progression of cancer. The role of the immune system in tumor progression is of relevance to the nervous system since they can bi-directionally communicate via neurotransmitters and neuropeptides, common receptors, and, cytokines. However, cross-talk between these cells is highly complex in nature, and numerous variations are possible according to the type of cancer involved. The neuro-immune interaction is essential in influencing cancer development and progression.

KEYWORDS:

Cancer-associated immune cells; Nervous system; Neuro-immune interaction; Neuropeptides; Neurotransmitters

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center