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Thromb Haemost. 2018 Jan;118(1):214-224. doi: 10.1160/TH17-07-0511. Epub 2018 Jan 5.

Rationale, Design and Methodology of the Computerized Registry of Patients with Venous Thromboembolism (RIETE).

Author information

1
Division of Cardiology, Department of Medicine, Columbia University Medical Center/New York-Presbyterian Hospital, New York, New York, United States.
2
Center for Outcomes Research and Evaluation (CORE), Yale University School of Medicine, New Haven, CT, USA.
3
Department of Respiratory, Hospital Ramón y Cajal, Universidad de Alcalá (IRYCIS), Madrid, Spain.
4
RIETE Registry Coordinating Center, S & H Medical Science Service, Madrid, Spain.
5
Department of Statistics, Universidad Autónoma de Madrid, S & H Medical Science Service, Madrid, Spain.
6
Vascular Medicine Unit, Department of Cardiovascular Sciences, University of Padua, Padua, Italy.
7
Department of Haematology and Bone Marrow Transplantation, Rambam Health Care Campus, Haifa, Israel.
8
Department of Vascular Medicine and Therapeutics, Hôpital Nord - CHU St-Etienne, Saint-Etienne, France.
9
Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States.
10
Department of Internal Medicine, Hospital General Universitario Santa Lucía. Murcia, Spain.
11
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States.
12
Department of Internal Medicine, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain.

Abstract

Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a preventable cause of in-hospital death, and one of the most prevalent vascular diseases. There is a lack of knowledge with regards to contemporary presentation, management and outcomes of patients with VTE. Many clinically important subgroups (including the elderly, those with recent bleeding and pregnant patients) have been under-represented in clinical trials. Furthermore, design of clinical trials is challenging in some scenarios, such as in those with hemodynamically unstable PE. RIETE (Registro Informatizado Enfermedad TromboEmbolica) is a large prospective multinational ongoing registry, designed to address these unmet needs using representative data from multiple centres. Initiated in Spain in 2001, RIETE currently includes 179 centres in 24 countries and has enrolled more than 72,000 patients. RIETE has helped characterize the pattern of presentation and outcomes of VTE, including the aforementioned understudied subgroups. RIETE has recently expanded to collect long-term outcome data, and has broadened its inclusion criteria to enrol other forms of venous thrombosis (such as cerebral vein thrombosis and splanchnic vein thrombosis). The RIETE platform is also being used to conduct pragmatic comparative effectiveness studies, including randomized trials. Future steps would focus on collaboration with additional centres across the world, and efforts to ensure the quality and expansion of the registry. In conclusion, RIETE is a large ongoing registry of patients with VTE and other thrombotic conditions. Its results could be helpful for improving our understanding of the epidemiology, patterns of care and outcomes of patients with thrombotic disease.

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