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Cell Stem Cell. 2018 Jan 4;22(1):12-13. doi: 10.1016/j.stem.2017.12.012.

Alpha to Beta Cell Reprogramming: Stepping toward a New Treatment for Diabetes.

Author information

1
Center for Stem Cell Biology and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA.
2
Center for Stem Cell Biology and Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: mark.magnuson@vanderbilt.edu.

Abstract

Beta cell replacement strategies hold promise for permanently treating type 1 diabetes. In Cell Stem Cell, Xiao et al. (2018) restore pancreatic beta cell mass and normalize blood glucose in diabetic mice by reprogramming pancreatic alpha to beta cells using Pdx1- and Mafa-expressing adeno-associated virus infused into the pancreatic duct.

PMID:
29304337
DOI:
10.1016/j.stem.2017.12.012
[Indexed for MEDLINE]
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