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Mol Cell. 2018 Jan 4;69(1):1-2. doi: 10.1016/j.molcel.2017.12.015.

Glutamate Dehydrogenase to the Rescue.

Author information

1
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jonathan_coloff@hms.harvard.edu.

Abstract

Tumor cell metabolism can be altered to support specific pathological functions or to adapt to environmental stresses. In this issue of Molecular Cell, Jin et al. (2018) identify induction of glutamate dehydrogenase as a critical metabolic adaptation in matrix-detached cancer cells that is required for metastasis of LKB1-deficient lung tumors.

PMID:
29304329
DOI:
10.1016/j.molcel.2017.12.015
[Indexed for MEDLINE]

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