Format

Send to

Choose Destination
Cell Mol Life Sci. 2018 Apr;75(8):1435-1444. doi: 10.1007/s00018-017-2737-0. Epub 2018 Jan 4.

Structure and function of the Nppa-Nppb cluster locus during heart development and disease.

Author information

1
Department of Medical Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. j.c.man@amc.uva.nl.
2
Department of Medical Biology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

Abstract

Atrial natriuretic factor and brain natriuretic peptide are two important biomarkers in clinical cardiology. These two natriuretic peptide hormones are encoded by the paralogous genes Nppa and Nppb, which are evolutionary conserved. Both genes are predominantly expressed by the heart muscle during the embryonic and fetal stages, and in particular Nppa expression is strongly reduced in the ventricles after birth. Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. Much is known about the molecular and physiological ques inducing Nppa and Nppb expression; however, the transcriptional regulatory mechanisms of the Nppa-Nppb cluster in vivo has proven to be quite complex and is not well understood. In this review, we will provide recent insights into the dynamic and complex regulation of Nppa and Nppb during heart development and hypertrophy, and the association of this gene cluster with the cardiomyocyte-intrinsic program of heart regeneration.

KEYWORDS:

Atrial and brain natriuretic peptide; Epigenetics; Gene cluster; Heart development; Heart regeneration; Hypertrophy; Super enhancer

PMID:
29302701
PMCID:
PMC5852170
DOI:
10.1007/s00018-017-2737-0
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center