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J Biol Chem. 2018 Feb 9;293(6):1865-1874. doi: 10.1074/jbc.R117.000366. Epub 2018 Jan 4.

The role of microRNAs in glucocorticoid action.

Author information

1
From the Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2WB.
2
the Arthritis Research UK Rheumatoid Arthritis Pathogenesis Centre of Excellence (RACE), Glasgow, Birmingham, and Newcastle Universities, Glasgow G12 8TA, Scotland, United Kingdom.
3
the Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, Scotland, and.
4
From the Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2WB, a.r.clark@bham.ac.uk.

Abstract

Glucocorticoids (GCs) are steroids with profound anti-inflammatory and immunomodulatory activities. Synthetic GCs are widely used for managing chronic inflammatory and autoimmune conditions, as immunosuppressants in transplantation, and as anti-tumor agents in certain hematological cancers. However, prolonged GC exposure can cause adverse effects. A detailed understanding of GCs' mechanisms of action may enable harnessing of their desirable actions while minimizing harmful effects. Here, we review the impact on the GC biology of microRNAs, small non-coding RNAs that post-transcriptionally regulate gene expression. Emerging evidence indicates that microRNAs modulate GC production by the adrenal glands and the cells' responses to GCs. Furthermore, GCs influence cell proliferation, survival, and function at least in part by regulating microRNA expression. We propose that the beneficial effects of GCs may be enhanced through combination with reagents targeting specific microRNAs.

KEYWORDS:

apoptosis; epigenetics; glucocorticoid; glucocorticoid receptor; inflammation; microRNA (miRNA)

PMID:
29301941
PMCID:
PMC5808749
DOI:
10.1074/jbc.R117.000366
[Indexed for MEDLINE]
Free PMC Article

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