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Int J Mol Sci. 2018 Jan 2;19(1). pii: E123. doi: 10.3390/ijms19010123.

Natural Antisense Transcripts: Molecular Mechanisms and Implications in Breast Cancers.

Author information

1
Laboratory of Human Genetics, GIGA-Institute, University of Liège, 4500 Liège, Belgium. g.latge@doct.ulg.ac.be.
2
Laboratory of Human Genetics, GIGA-Institute, University of Liège, 4500 Liège, Belgium. christophe.poulet@ulg.ac.be.
3
Laboratory of Human Genetics, GIGA-Institute, University of Liège, 4500 Liège, Belgium. vbours@ulg.ac.be.
4
Center of Genetics, University Hospital (CHU), 4500 Liège, Belgium. vbours@ulg.ac.be.
5
Laboratory of Human Genetics, GIGA-Institute, University of Liège, 4500 Liège, Belgium. c.josse@chu.ulg.ac.be.
6
Department of Medical Oncology, University Hospital (CHU), 4500 Liège, Belgium. c.josse@chu.ulg.ac.be.
7
Laboratory of Medical Oncology, GIGA-Institute, University of Liège, 4500 Liège, Belgium. c.josse@chu.ulg.ac.be.
8
Department of Medical Oncology, University Hospital (CHU), 4500 Liège, Belgium. g.jerusalem@chu.ulg.ac.be.
9
Laboratory of Medical Oncology, GIGA-Institute, University of Liège, 4500 Liège, Belgium. g.jerusalem@chu.ulg.ac.be.

Abstract

Natural antisense transcripts are RNA sequences that can be transcribed from both DNA strands at the same locus but in the opposite direction from the gene transcript. Because strand-specific high-throughput sequencing of the antisense transcriptome has only been available for less than a decade, many natural antisense transcripts were first described as long non-coding RNAs. Although the precise biological roles of natural antisense transcripts are not known yet, an increasing number of studies report their implication in gene expression regulation. Their expression levels are altered in many physiological and pathological conditions, including breast cancers. Among the potential clinical utilities of the natural antisense transcripts, the non-coding|coding transcript pairs are of high interest for treatment. Indeed, these pairs can be targeted by antisense oligonucleotides to specifically tune the expression of the coding-gene. Here, we describe the current knowledge about natural antisense transcripts, their varying molecular mechanisms as gene expression regulators, and their potential as prognostic or predictive biomarkers in breast cancers.

KEYWORDS:

breast cancer; gene expression regulation; lncRNA; natural antisense transcript; natural antisense transcripts; next generation sequencing; non-coding RNA

PMID:
29301303
PMCID:
PMC5796072
DOI:
10.3390/ijms19010123
[Indexed for MEDLINE]
Free PMC Article

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