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Mar Drugs. 2018 Jan 4;16(1). pii: E1. doi: 10.3390/md16010001.

The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation.

Author information

1
NTT Institute of Hi-Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam. vtsang@ntt.edu.vn.
2
Department of Marine Life Science, College of Ocean Science and Technology, Korea Maritime and Ocean University, Busan 606-791, Korea. sknkim@pknu.ac.kr.
3
School of Pharmacy, the University of Queensland, Brisbane QLD 4072, Australia. ryu.bomi@gmail.com.
4
Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, Vietnam. hungdaingo83@yahoo.com.
5
Food and Safety Research Center, National Fisheries Research & Development, Busan 46083, Korea. dbssud@hanmail.net.
6
Department of Science and Technology, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam. blgiang@ntt.edu.vn.
7
Faculty of Natural Sciences, Thu Dau Mot University, Thu Dau Mot City 820000, Binh Duong Province, Vietnam. hangntn@tdmu.edu.vn.
8
Faculty of Chemistry, University of Science-VNU-HCM City, 227 Nguyen Van Cu Street, Ho Chi Minh City 700000, Vietnam. hangntn@tdmu.edu.vn.
9
Department of Biochemistry, Faculty of Biology and Biotechnology, University of Science, Vietnam National University, Ho Chi Minh City 700000, Vietnam. ndnghiep@hcmus.edu.vn.

Abstract

UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction.

KEYWORDS:

Ecklonia stolonifera; Fucofuroeckol-A; anti-allergy; degranulation; mast cells; phlorotannin

PMID:
29300311
PMCID:
PMC5793049
DOI:
10.3390/md16010001
[Indexed for MEDLINE]
Free PMC Article

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