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Sci China Life Sci. 2017 Dec;60(12):1357-1363. doi: 10.1007/s11427-017-9263-6. Epub 2017 Dec 1.

The persistent prevalence and evolution of cross-family recombinant coronavirus GCCDC1 among a bat population: a two-year follow-up.

Obameso JO1,2, Li H3, Jia H4,5, Han M1, Zhu S4,5, Huang C5, Zhao Y1, Zhao M1,2, Bai Y1,2, Yuan F1, Zhao H5, Peng X3, Xu W3, Tan W5, Zhao Y5, Yuen KY6, Liu WJ4,5, Lu L7, Gao GF8,9,10.

Author information

1
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China.
2
University of Chinese Academy of Sciences, Beijing, 100049, China.
3
Yunnan Provincial Center for Disease Control and Prevention, Kunming, 650022, China.
4
College of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
5
Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China.
6
State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
7
Yunnan Provincial Center for Disease Control and Prevention, Kunming, 650022, China. lulin@yncdc.cn.
8
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. gaofu@chinacdc.cn.
9
University of Chinese Academy of Sciences, Beijing, 100049, China. gaofu@chinacdc.cn.
10
Key Laboratory of Medical Virology and Viral Diseases, Ministry of Health of People's Republic of China, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. gaofu@chinacdc.cn.

Abstract

Bats are connected with the increasing numbers of emerging and re-emerging viruses that may break the species barrier and spread into the human population. Coronaviruses are one of the most common viruses discovered in bats, which were considered as the natural source of recent human-susceptible coronaviruses, i.e. SARS-COV and MERS-CoV. Our previous study reported the discovery of a bat-derived putative cross-family recombinant coronavirus with a reovirus gene p10, named as Ro-BatCoV GCCDC1. In this report, through a two-year follow-up of a special bat population in one specific cave of south China, we illustrate that Ro-BatCoV GCCDC1 persistently circulates among bats. Notably, through the longitudinal observation, we identified the dynamic evolution of Ro-BatCoV GCCDC1 in bats represented by continuously recombination events. Our study provides the first glimpse of the virus evolution in one longitudinally observed bat population cohort and underlines the surveillance and pre-warning of potential interspecies transmittable viruses in bats.

KEYWORDS:

bat population; coronavirus; evolution

PMID:
29299855
DOI:
10.1007/s11427-017-9263-6
[Indexed for MEDLINE]

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