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Avicenna J Phytomed. 2017 Nov-Dec;7(6):554-564.

Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia.

Author information

1
Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran.
2
Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran.
3
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
4
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of MedicalScience, Kerman, Iran.
5
Biostatistics and Epidemiology Department, Modeling in Health Research Center, Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran.
6
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran.
7
Pharmaceutical Research Center & Department of Medicinal Chemistry, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.

Abstract

Objectives:

This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD).

Material and Methods:

In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test.

Result:

In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects.

Conclusion:

According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients.

KEYWORDS:

Apium graveolens; Carum copticom; Functional Dyspepsia; Iranian Traditional medicine

PMID:
29299438
PMCID:
PMC5745539

Conflict of interest statement

The authors declare that there is no conflict of interests.

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