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J Orthop Surg Res. 2018 Jan 3;13(1):1. doi: 10.1186/s13018-017-0693-x.

Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon.

Author information

1
Department of Physical and Rehabilitation Medicine, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Gangnamgu, Irwonro, 81th street, Seoul, 135-710, South Korea. catedral.sjk@gmail.com.
2
Department of Physical and Rehabilitation Medicine, Stem Cell & Regenerative Medicine Institute, Samsung Medical Center, Gangnamgu, Irwonro, 81th street, Seoul, 135-710, South Korea.

Abstract

BACKGROUND:

We compared the clinical course of rotator cuff tears between rotator cuff exercise and bone marrow aspirate concentration (BMAC)-platelet rich plasma (PRP) injection to identify the therapeutic effects of BMAC-PRP on partial tear of the rotator cuff tendon.

METHODS:

Twenty-four patients with partial tear of the rotator cuff tendon participated in this study. Twelve patients underwent extraction of BMACs and PRP and received the injection of BMAC-PRP at the tear site under ultrasound guidance. Twelve patients in the control group were asked to perform the rotator cuff exercise for 3 months. Visual analog scale (VAS) and manual muscle test (MMT) scores of the supraspinatus muscle were measured, and the American Shoulder and Elbow Surgeons (ASES) score was recorded before, 3 weeks, and 3 months after injection. Tear size was measured by the greatest longitudinal tear length.

RESULTS:

The change in the VAS differed between groups at 3 months (P = 0.039) but not at 3 weeks (P = 0.147). The ASES scores in the BMAC-PRP group changed from 39.4 ± 13.0 to 54.5 ± 11.5 at 3 weeks and 74.1 ± 8.5 at 3 months while those in the control group changed from 45.9 ± 12.4 to 56.3 ± 12.3 at 3 weeks (P = 0.712) and 62.2 ± 12.2 at 3 months (P = 0.011). The tear size decreased at 3 weeks or 3 months after the BMAC-PRP injection but was not significantly different from that in the control group.

CONCLUSIONS:

BMAC-PRP improved pain and shoulder function in patients with partial tear of the rotator cuff tendon.

TRIAL REGISTRATION:

The patients were registered in the institutional board registry of Samsung Medical Center (registry number 2014-07-173 ).

KEYWORDS:

Bone marrow aspirates; Degeneration; Platelet-rich plasma; Rotator cuff tear

PMID:
29298726
PMCID:
PMC5753487
DOI:
10.1186/s13018-017-0693-x
[Indexed for MEDLINE]
Free PMC Article

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