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Cell Rep. 2018 Jan 2;22(1):175-188. doi: 10.1016/j.celrep.2017.12.029.

The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity.

Author information

1
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: christina.christoffersen@regionh.dk.
2
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark.
3
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
4
Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Novo Nordisk Center for Basic Metabolic Research, University of Copenhagen, 2200 Copenhagen, Denmark.
5
Department of Biochemistry and Molecular Cell Biology, Universitätsklinikum Hamburg-Eppendorf, 20246 Hamburg, Germany.
6
Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, 2200 Copenhagen, Denmark.
7
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark; Department of Biomedical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, 2200 Copenhagen, Denmark. Electronic address: larsbo@au.dk.

Abstract

Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

KEYWORDS:

apoM; apolipoproteins; brown adipose tissue; lipid metabolism; lipoproteins; sphingolipids; sphingosine-1-phosphate; triglyceride

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PMID:
29298420
DOI:
10.1016/j.celrep.2017.12.029
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