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Microb Drug Resist. 2018 May;24(4):455-460. doi: 10.1089/mdr.2017.0124. Epub 2018 Jan 3.

Longitudinal Case Series of Staphylococcus aureus Colonization and Infection in Two Cohorts of Rural Iowans.

Author information

1
1 Department of Biostatistics, Environmental Health Sciences, and Epidemiology, College of Public Health, Kent State University , Kent, Ohio.
2
2 Clinical Research Division, Fred Hutchinson Cancer Research Center , Seattle, Washington.
3
3 Division of Infectious Disease, Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison , Madison, Wisconsin.

Abstract

OBJECTIVE:

Examine the relationship between colonization with Staphylococcus aureus in the community and symptomatic infection in two cohorts of Iowans.

DESIGN:

Case series within cohort study.

PARTICIPANTS:

Rural Iowans selected from the Keokuk Rural Health Study, the Agricultural Health Study, and the Iowa Voter Registry.

METHODS:

Longitudinal study within established cohorts evaluating documented S. aureus infections with samples available for molecular typing.

RESULTS:

We examined this relationship in two cohorts of Iowans with a combined 11 incident cases of S. aureus SSTI, for which samples were available. Seven of the 11 individuals (63.6%) were colonized at baseline, in the nose (3/7, 42.9%), or in both the nose and throat (57.1%). All seven cases had matching sequence types between colonization and infection isolates.

CONCLUSIONS:

Staphylococcus aureus causes millions of skin and soft tissue infections yearly. Although colonization with S. aureus is a frequent antecedent to infection, many studies investigating the link between colonization and infection have taken place in a clinical setting, particularly in urban hospitals. Our study has shown similar results in a rural community setting to those previously seen in clinics.

KEYWORDS:

MRSA; antibiotic resistance; epidemiology; skin infection; soft tissue infection

PMID:
29298107
DOI:
10.1089/mdr.2017.0124
[Indexed for MEDLINE]

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