Format

Send to

Choose Destination
Int J Radiat Biol. 2018 Mar;94(3):212-228. doi: 10.1080/09553002.2018.1422871. Epub 2018 Jan 10.

Chronic fatigue and immune deficiency syndrome (CFIDS), cellular metabolism, and ionizing radiation: a review of contemporary scientific literature and suggested directions for future research.

Author information

1
a Department of Biology , McMaster University , Hamilton , Canada.
2
b Medical Physics and Applied Radiation Sciences , McMaster University , Hamilton , Canada.

Abstract

PURPOSE:

To investigate biochemical pathways known to be involved in radiation response and in CFIDS to determine if there might be common underlying mechanisms leading to symptoms experienced by those accidentally or deliberately exposed to radiation and those suffering from CFIDS. If such a link was established to suggest testable hypotheses to investigate the mechanisms with the aim of identifying new therapeutic targets.

CONCLUSIONS:

Evidence for involvement of the alpha-synuclein, cytochrome c oxidase, αB-crystallin, RNase L, and lactate dehydrogenase/STAT1 pathways is strong and suggests a common underlying mechanism involving mitochondrial dysfunction mediated by ROS and disruption of ATP production. The downstream effect of this is compromised energy production. Testable hypotheses are suggested to investigate the involvement of these pathways further.

KEYWORDS:

Chronic fatigue syndrome; atomic veterans; bystander effects of radiation; post-radiation syndrome; reactive oxygen species (ROS)

PMID:
29297728
DOI:
10.1080/09553002.2018.1422871
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Taylor & Francis
Loading ...
Support Center