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Mov Disord. 2018 Mar;33(3):472-478. doi: 10.1002/mds.27239. Epub 2018 Jan 3.

Selected health and lifestyle factors, cytosine-adenine-guanine status, and phenoconversion in Huntington's disease.

Author information

1
Parkinson's Disease Research, Education and Clinical Center, Neurology, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA.
2
Department of Neurology, University of California-San Francisco, San Francisco, California, USA.
3
Departments of Neurology and Psychiatry, Taub Institute for Research on the Aging Brain, Gertrude H. Sergievsky Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.
4
Department of Biostatistics and Computational Biology, University of Rochester, New York, New York, USA.
5
Eli Lilly and Company, Indianapolis, Indiana, USA.
6
Department of Neurology, University of Rochester, New York, New York, USA.
7
Department of Neurology, Georgetown University, Washington, D.C., USA.

Abstract

BACKGROUND:

In Huntington's disease, 60% of the variance in onset age is not explained by the huntingtin gene mutation. Huntington's disease onset was earlier in caffeine users.

OBJECTIVE:

The objective of this study was to assess the relationship of lifestyle factors with motor phenoconversion among persons at risk for Huntington's disease.

METHODS:

The associations of motor phenoconversion and exposure to selected lifestyle and health factors were examined using Cox proportional hazards analyses adjusted for age, gender, and repeat length.

RESULTS:

Of 247 participants, 36 (14.6%) phenoconverted. Mean follow-up was 4.2 years. Greater caffeinated soda use was associated with an increased hazard of phenoconversion: moderate use hazard ratio 2.26 (95% confidence interval 0.59-8.71), high use hazard ratio 4.05 (95% confidence interval 1.18-13.96).

CONCLUSIONS:

Huntington's disease onset was earlier among consumers of caffeinated soda, but not other caffeinated beverages. This finding may be spurious or not related to caffeine. © 2018 International Parkinson and Movement Disorder Society.

KEYWORDS:

CAG repeat; Huntington's disease; caffeine; environment; phenoconversion

PMID:
29297592
PMCID:
PMC5986294
[Available on 2019-03-01]
DOI:
10.1002/mds.27239

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